Transfer verzoegert sich

Re: Transfer verzoegert sich

Hallo!

Ich persoenlich bin stark dagegen, spaeter als Tag 22-23 zu trsanferieren. Es gibt aber viele Studien, die gezeigt haben, dass man mehr als 30 Tage mit Oestrogene ziehen kann mit den guten Schwangerschaftsraaten, natuerlich,wenn keine Blutung inzwischen passiert (hab die Sammlung irgendwo im Buhro, werde morgen Ihnen hier zeigen).

Ich wuerde zu dem Blastozysttransfer ueberzeugend raten. Es gibt auch Studien nach denen das Blastozystransfer das spaeten Transfer gut retten kann.

Also wenn keine Blutung und Blastocysttransfer, kann alles gut sein.
Was fuer Motivation fuer das fruheren Transfer bei Ihrer Klinik? Das Embryo wird doch nicht fruher einnisten.

Bis morgen
Gruss
Dr. Zaytseff

Re: Transfer verzoegert sich

Hallo Sarah!
Wo bekommen Sie Ihre Behandlung?
Hab keine Ahnung, warum Sie diese 2 sehr Starke Antibiotika nehmen. Das Muessen Sie mir sagen.
Blastocystentransfer wenn nur 5 Eizellen befruhtet sind macht leider keinen Sinn aus Selktionsgrunden.
Wuerde auf keinem Fall Progynova reduziren

Hier sind die Studien ueber lange Oestrogentherapie bei Eizellpsende, die Ich Ihnen versprochen habe.
Viele Gruesse
Dr. Zaytseff

1: Hum Reprod. 1995 Jun;10(6):1387-91. Links
Long oestradiol replacement in an oocyte donation programme.
Remohí J, Gutiérrez A, Cano F, Ruiz A, Simón C, Pellicer A.
Instituto Valenciano de Infertilidad, Valencia University School of Medicine, Spain.
The objective of this study was to optimize, in terms of endometrial receptivity (embryo implantation), the limits of unopposed administration of oestrogens beyond 35 days in an in-vitro fertilization (IVF) and ovum donation programme. Oocytes donated by 182 women undergoing IVF were distributed among 186 women treated by ovum donation. Five groups of recipients were established according to the duration of oestradiol valerate administration, in a 'prolonged follicular phase' protocol, before embryo replacement, employing oestradiol valerate at increasing doses up to 6 mg/day. Gonadotrophin-releasing hormone analogues (GnRHa) were simultaneously administered in ovulatory patients. The dosage of oestradiol valerate was maintained until oocytes were available for insemination and subsequent transfer. Donors and recipients were equally distributed among groups in terms of age and cause of infertility. There was no difference among groups in serum oestradiol concentration the day in which progesterone was added to obtain a secretory transformation of the endometrium. An analysis of the ovum donation cycles showed no difference among groups in pregnancy and implantation rates after the replacement of a similar number of embryos. Successful implantation was observed even after 100 days of unopposed oestradiol valerate administration. Break-through bleeding increasingly appeared according to the duration of oestrogen replacement. These clinical observations provide evidence that the concept of 'prolonged follicular phase' oestrogen replacement for ovum donation can be maintained, at least as long as 15 weeks. However, because of the high (> 44%) incidence of break-through bleeding after 9 weeks, it is advisable to stop oestrogen treatment at this point.(ABSTRACT TRUNCATED AT 250 WORDS)

1: J In Vitro Fert Embryo Transf. 1991 Apr;8(2):84-8. Links
The effect of a prolonged artificial follicular phase on endometrial development in an oocyte donation program.
Younis JS, Mordel N, Ligovetzky G, Lewin A, Schenker JG, Laufer N.
Department of Obstetrics & Gynecology, Hadassah University Hospital, Ein-Karem, Jerusalem, Israel.
Stretching the duration of an artificial follicular phase in an oocyte donation program facilitates greatly the synchronization between the donor and the recipient. In order to investigate the limits of such a prolonged endometrial preparation, 18 patients with ovarian failure were studied during 20 treatment cycles. These patients were prospectively and randomly divided into three groups (A, B, and C in eight, six, and six cycles respectively). All groups were treated with oral estradiol and estriol (at a 2:1 ratio), 4 mg/day for 21, 28, and 35 days, respectively. At this stage 50 mg/day of intramuscular progesterone was added for additional 7 days. Endometrial adequacy was evaluated by late follicular and midluteal endometrial biopsies. During treatment no patient suffered from breakthrough bleeding. The mean estradiol and progesterone levels during the follicular and luteal phases did not differ significantly between groups. All late follicular biopsies showed a normal proliferative endometrium with no signs of glandular cystic hyperplasia. The midluteal biopsy showed a secretory endometrium adequate for 18.6 +/- 1.8, 21.8 +/- 1.8, and 18.6 +/- 1.5 days in groups A, B, and C, respectively, with no significant glandular-stromal disparity. We conclude that an artificial prolonged follicular phase does not seem to affect adversely the endometrial preparation in an oocyte donation program.
PMID: 2061684 [PubMed - indexed for MEDLINE]

Re: Transfer verzoegert sich

Ich wuanesch Ihnen ein einfaches und erfokgreiches Transfer.
Gruss
Dr. Z.