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40, desire to have children, insecure

  • Ginileinchen
  • July 2, 2025 at 11:06 PM
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  • Ginileinchen
    Eizelle
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    • July 2, 2025 at 11:06 PM
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    Hello everyone,


    I am completely unsettled and frankly overwhelmed. We've been trying to conceive since we got married in 2018. Unfortunately, I didn't get pregnant and was never really able to determine my ovulation with ovulation tests and temperature methods. We went to a fertility clinic for the first time in 2020. My husband's spermiograms were great and my hormones etc. were also good. However, my BMI was over 35 and the doctor there told me that she wouldn't even do cycle tracking with ovulation triggering on me because she couldn't dose my hormones properly... However, the fallopian tube permeability was checked.
    This experience and the corona restrictions etc. led to the fact that we only found the courage to try again in another fertility center in 2024. Here my hormones were also found to be ok and spermiograms were good and at the end of 2024 we had first triggered ovulation with Ovitrelle for three months and tried to get pregnant naturally until the health insurance companies had approved the treatment plan. However, as I will be 40 in September this year, we decided to start as soon as possible and then had IVF at the beginning of 2025, where 11 eggs were also retrieved. We were in high spirits and then came the shock - none of the eggs fertilized. I was completely stunned. Our doctor said it might be due to the calcium channel of the sperm and that we would definitely get fertilized eggs with an Icsi.
    So we immediately had the treatment plan for Icsis drawn up and out of 9 follicles, 7 eggs were mature. But the next blow - only one egg was fertilized! This egg divided on the morning of the second day and we had a beautiful 4 AA cell, which was transferred to me on day 2. Unfortunately, it either didn't divide any further or didn't implant.

    We then needed a break and there were various public holidays in Bavaria, so we only had our second Icsi last week. This time I felt different to the other two stimulations and I had a viral upper respiratory tract infection with laryngitis just before and at the beginning of the cycle. Nevertheless, the stimulation was the same as with the first Icsi. This time the puncture revealed only 5 eggs and only 3 of them were mature. The sperm were selected with Zymot chamber and the eggs were placed in calcium ionophore. Again, only one egg was fertilized. On the day of the planned transfer, I was called to say that this egg had also failed to divide. Desperation.

    This was the last attempt in which the health insurance company was involved.

    My husband has now received the results of the DNA fragmentation and everything looks good (we are still waiting for all our documents!).

    On the phone I was told by the doctor that with our fertilization rate he can't advise me to try again with my own eggs.

    In the meantime, I wish we had gone back to another fertility center. My doctor was unavailable most of the time and I saw many different doctors. Even after the unsuccessful attempts, there was often no contact person available to discuss the next steps properly. My husband was usually completely ignored. He wasn't supposed to come to the appointments either, except for blood tests and sperm collection. I was often not called back as agreed or at other times (e.g. when I was at the gym) and I could neither talk freely nor take notes etc.

    I don't know if I want to give up yet. But I'm also overwhelmed by the possibilities at the moment.
    We live in southern Germany, so the Czech Republic and Austria would be good options for treatment abroad.

    I have asked a Spanish clinic for an online consultation as they offer "ovarian rejuvenation" - do you have any experience or opinions?

    What are your opinions and experiences of double IVF? Does it make sense at all if the egg quality is poor?

    Is there a test to determine the quality of the eggs, I couldn't really find anything on this.

    I am now so confused and unsure that I can no longer absorb the information I am researching.
    Our fertility center uses a portal where all results are supposed to be uploaded, but blood values have only been uploaded once, although we have asked for our values several times...

    Sorry for the long text, I guess it all had to come out.

    Have a nice evening and best regards ;(

  • Oskar
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    • July 3, 2025 at 12:10 AM
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    Dear Ginileinchen,

    First of all, give yourself a big hug! You've really been through a lot, I can understand your despair!

    I'm afraid that ovarian rejuvenation hasn't really been "invented" yet, but is still being tested. A test for egg quality would be really cool, but it doesn't exist either. We can only make indirect assumptions about quality based on statistics and age.

    Best regards! Your Oskar

  • Oskar
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    • July 3, 2025 at 10:40 AM
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    Dear Ginileinchen,

    I was a bit tired yesterday ;-). I wanted to explain again why I doubt that ovarian rejuvenation is difficult in my opinion:

    After all, a woman's egg reserve is already created in the embryonic phase and cell division is paused. The chromosomes are attached to the cell division spindle and it is precisely this spindle (microtubules) that can become fragile over the decades, which can then lead to maldistribution of the chromosomes during the next stage of development (during follicle maturation). It is a bit of a mystery to me how treatment with autologous blood/stem cells can repair these microtubules; I doubt that this is possible. But what could theoretically be possible: stem cells were found in the ovaries of the mouse (I think this was published in 2019, at least not too long ago), which means that the woman's ovaries may also have stem cells, but they are "hidden" due to some evolutionary development. Then it might theoretically be possible to activate them at some point and the ticking of the biological clock might become quieter. Maybe there is something like this in the ovarian rejuvenation procedure, but as far as I know there is no real scientific proof.

    Best regards! Oskar

  • Oskar
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    • July 3, 2025 at 10:46 AM
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    P.s: I was a bit shocked to read that your first doctor said you couldn't dose the hormones because of your BMI... she didn't even try?

  • Ginileinchen
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    • July 4, 2025 at 5:56 PM
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    Hello Oskar, thank you for your answers!
    Yes, unfortunately I had only found that there is no scientific evidence for the effectiveness of this "ovarian rejuvenation".
    What do you think of double IVF, i.e. retrieving eggs twice in a cycle? I hadn't heard of this at all in the fertility center in Germany and have just now stumbled across it during my first research.


    My husband would actually like to try an Icsi again in Germany because we still have no idea how it will work organizationally abroad, so far we have only contacted one clinic in Spain and have not yet had an appointment.


    Yes, I was also shocked that the doctor at the first Kiwu center didn't want to help me at all. She didn't even want to monitor my ovulation after I had such different results from the ovulation tests and the temperature method. I just wanted to know if I was ovulating at all and she didn't even want to do that. They wanted to do the triggering with clomiphene and she didn't think it was possible to determine the dose with my weight (I weighed about 114 kg).


    As a result, I fell into a hole and continued to put on weight. Then I lost weight again and went to the new fertility clinic with the same weight in 2024 and they said that it wasn't a problem at all.
    I have since lost a lot more weight and weigh under 90kg. We had hoped that the weight loss would help with the desire to have children, but that wasn't the problem at all.

    I'm undecided whether we should try again in Germany. So far, this experience has been so disappointing and I don't know whether I shouldn't invest the money directly in an egg donation.

    How do you finance all these trips and treatments?
    I haven't gotten this far in the forum yet, sorry if this is already all over the place....

    I got my period yesterday (ZT 21) after I didn't have a transfer, it was to be expected that it would start soon, but it still hit me terribly and made me sad again.
    And now with the nice weather, I only see pregnant women or families with children everywhere again and I just want a family too 😢


    Thank you and best wishes,

    Ginileinchen

  • Oskar
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    • July 5, 2025 at 12:36 AM
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    Dear Ginileinchen,

    I would say that double IVF would primarily be good for your wallet, because the most expensive thing is the laboratory for artificial insemination. It doesn't make much difference in the lab whether you fertilize two or ten eggs. I don't really see why double IVF shouldn't be possible in Germany. Why IVF and not ICSI? Incidentally, the eggs are not retrieved twice in one cycle, but collected from two cycles,

    Best regards!

    Oskar

    pS: I know the sadness when the days come ;(

    I can't tell you what chances you have with your eggs, it's probably always a game of chance when you're not quite so young... I was pregnant a lot of times, but lost them all...

  • C+C_Schmid
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    • July 5, 2025 at 3:36 PM
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    Ginileinchen IVF Naturelle might also be possible in your case

    LG

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  • Ginileinchen
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    • July 6, 2025 at 10:56 PM
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    Quote from Oskar

    Dear Ginileinchen,

    I would say that double IVF would primarily be good for your wallet, because the most expensive thing is the laboratory for artificial insemination. It doesn't make much difference in the lab whether you fertilize two or ten eggs. I don't really see why double IVF shouldn't be possible in Germany. Why IVF and not ICSI? Incidentally, the eggs are not retrieved twice in one cycle, but collected from two cycles,

    Best regards!

    Oskar

    pS: I know the sadness when the days come ;(

    I can't tell you what chances you have with your eggs, it's probably always a game of chance when you're not quite so young... I was pregnant a lot of times, but lost them all...

    Display More


    Hello Oskar,

    Yes, double IVF is done in one cycle, but yes, I wouldn't have IVF done but ICSI, IVF didn't work for us at all... but I had only just read that at this Kiwu clinic, in Germany they hadn't mentioned anything like that. I just don't know whether it makes sense, because the eggs are frozen and that's certainly not the best option if the quality is poor... and we never got any embryos (except for the one transfer of the 4 cells)...

    I'm very sorry that you lost all your pregnancies, feel hugged 🫂

  • Post by Ginileinchen (July 6, 2025 at 10:57 PM).

    This post was deleted by the author themselves (July 6, 2025 at 11:00 PM).
  • Ginileinchen
    Eizelle
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    • July 6, 2025 at 11:02 PM
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    Quote from C+C_Schmid

    Ginileinchen IVF Naturelle might also be possible in your case

    LG

    Claudia & Chris

    Hello Claudia and Chris,

    But with IVF Naturelle, only one egg is retrieved, isn't the probability of success even worse if the quality is poor? Or are the eggs better if they can mature on their own than if several mature?
    Thank you and best wishes,

    ginileinchen

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