1. EZS negative

Dear Lene1980, I'm really very sorry that it didn't work out. Unfortunately, even an EZS is no guarantee that it will work immediately. However, this is definitely not due to age. In most cases, age is precisely the reason for considering an ECS. So it's completely absurd to slap on such an "explanation" and also not very sensitive.

Unfortunately, there are many factors that are responsible for implantation and not all of them are known. Even a young, healthy woman without any restrictions does not always get pregnant spontaneously after one cycle, even if the man has healthy sperm and they have caught the absolute best time.

Don't give up. The journey is not over yet. But it would be worth asking whether you need a few more tests, e.g. for adenomyosis or endometriosis.

Give yourself a big hug

Dear Lene 1980,

First of all, my sympathy for what you have experienced! You can complain at any time and I find the coordinator's statement extremely unsympathetic and also not real. There are an infinite number of reasons and unfortunately not every EZS cycle leads to success. Sometimes it takes several attempts.

The late appointment for the meeting is annoying, that really bothered me during the last failed transfer. I would have urgently needed a timely exchange! What was your treatment protocol like? Are there any immunological factors that could be taken into consideration? That was my clinic's first approach, but I had a biochemical SS.

Don't give up, process everything you've experienced and create new hope. The limit has not yet been reached. I keep my fingers crossed from the bottom of my heart and wish you lots of strength and confidence.

Tascha0205

Hello dear Lene1980!

First of all, I would like to say that I am also in my 80s and have endo grade 4.

It was exactly three years ago that I had my last endo reconstruction and my professor did a great job. I am completely symptom-free and the doctor at our Czech clinic said at the initial examination that there was no sign of endometriosis and therefore she didn't think down-regulation was necessary, but more on that in a moment!

We went to the initial consultation at the Czech clinic last June. The donor was practically already available. She is 32 years old and the result of the donation was very good! 12 eggs, 11 could be fertilized, 9 blastos !!! And now comes a fact that I would like to point out again and again - we had the blastos tested and three blastos were genetically abnormal - there was even a 5AA blasto among the abnormal ones!!!!

You can see from our result that even in a 32-year-old donor three blastos were not OK. If we had had these implanted, it would have been the most pleasant option if it had simply not worked out. But of course it could also have ended in miscarriages or diagnoses for the child.

We wanted to avoid this as much as possible because our path (even with miscarriages) is already too long!

So the failure of the first EZS must have nothing to do with possible problems for you - or have your blastos also been tested?

The age thing is complete nonsense - in my case it worked immediately with the first healthy blasto!!! We chose a simple protocol without downregulation as I had had bad experiences with this in the past!!!

The doctor at the initial examination told us that it can take up to three attempts, even with a donation...

If most of the tests have been carried out on you and there are no clues apart from the endo, don't be discouraged and certainly not by your age!!!

And you have already had a child - i.e. your body can conceive and carry a child!!!

You can take small supplements in advance for all these issues (e.g. aspirin, high doses of omega-3 in capsules or as an infusion, vitamin D, building up vaginal flora.... and so on and so forth).

Have you done anything?

Very LG

Dear Lene 1980,

Of course everything can be sh...... The treatments and the hopes placed in them do something to you.

I am not an expert either, I can only report on my own experiences. I was told in the expert consultation that it often doesn't work the first time. If age were the obstacle to success, then this option would not exist with EZS and we would be able to follow wonderful stories here.

I would first of all keep your thoughts in mind and ask your questions to the clinic.

Don't give up - I absolutely still see chances and your age still allows some time.

I understand the scheme F, but the protocol was only changed for me on the third attempt.

Intralipid and Omegaven are often a choice for repeated implantation failure. After the 2nd biochemical SS, a biopsy was suggested, which unfortunately yielded no results, or nothing that would have prevented successful implantation. Without increased killer cells, Intralipid was administered at the third attempt and Ovitrelle from transfer 6 clicks. Unfortunately also without success. The fourth attempt the clinic would continue with the same protocol.

My protocol: 8mg Estrifam, 800mg Cyglogest, 25mg Prolutex, Ass,Clexane and in addition the last two drugs mentioned. The forum doctor here suggested checking the Kir HCLA.

In which country are you being monitored?

Dear Lene,

We are undergoing treatment in Madrid! Unfortunately unsuccessful so far!

LG Tascha

Dear Lene,

the statement about the age of an EZS is total nonsense. I had an implantation at 49 for the first time and then got pregnant again at 50 (I will now be a mom in 4 weeks). I've also had endo, adeno, fibroids etc but I'm still happily rolling balls at the moment

I was also in Spain without success (same protocol). Only had one biochemical + 2 negative transfers.

Then I went to Greece because of age and only got pregnant on the first try with Estrifam and Prolutex.

I firmly believe that (a) sometimes you just need multiple tries, and (b) sometimes the donor just isn't a match. (c) I would always use a donor under 30, but that's really just my personal opinion...

All the protocols and additional tests (and I've done EVERYTHING and spent thousands of dollars on them) are just an afterthought and often don't accomplish anything except making you feel like you've done something.

What is important is the uterus - I also had endo, adeno, fibroids - everything. I then had a fibroid operation and cleared everything up. That was the only difference between unsuccessful and successful transfers. Of course, I am not a doctor and am only reporting from my personal experience.

So, I think you should keep trying, only after 3-4 attempts without results would I start to worry again. and as I said, I wouldn't spend so much money on immune tests etc. these days and I wouldn't just inject Clexane on suspicion, but rather rehabilitate the uterus. I also had a downregulation (without result). Incidentally, all the doctors were always against an operation! I just stood my ground and it worked. Otherwise I always felt like a guinea pig for their "protocols"

Hello Lene,

My situation is a bit similar to yours: I got pregnant on my first attempt in 2020, but directly with egg donation, as nothing else was an option for us, and then had two failed attempts for a sibling. I hope to have my third attempt in Aarhus soon, I had my consultation with the doctor today. Nothing was changed in our protocol, except that I am now supposed to take additional prednisolone. However, the doctor said that there is no evidence that it does any good, but it doesn't do any harm either. She also recommended that I have a hysteroscopy to detect any undetected obstructions. As for everything else I asked her about, such as the KIR/HLA test, dietary supplements, ERA test, she just said that there was no evidence for this and as long as there was no evidence, it was just a money-making exercise...

That sounds very good 👍🏼

I'm keeping my fingers crossed for Friday. Hats off to you for not testing yourself.... I couldn't do that

What do you mean you moved away from Ferticare? Did you change clinics? And were you able to take your Blastos with you?

Dear Lene1980, I'm also keeping my fingers crossed for you!!!! Best regards! Oskar

Hello everyone, was it the same for you after the first unsuccessful transfer that the doctor treating you did not plan to change anything for the second transfer? For example, no further diagnostics, no adjustment of medication or similar?

I had a conversation with my doctor today after the first transfer, which was unfortunately unsuccessful, and he is planning to keep everything exactly the same and I am really unsure. I'm having a plasma cell test myself, which he doesn't think is necessary, although there is even a suspicion from a uterine endoscopy... Apart from that, he didn't advise me to do anything, just try again. In your opinion or experience, is this "normal"?

We only have one more blasto on ice. After that it would be: everything back to square one 😒.

Best regards

It was the same with us. I don't know whether that makes sense or not, but it's certainly not unusual. Many clinics only start looking for causes after two or three failed attempts.

It's really not unusual. Even with EZS, you don't have a 100% pregnancy rate on the first attempt. On the contrary. Often nothing needs to be adjusted at all, but it simply takes several attempts.

You don't get pregnant every time just because you have sex on your fertile days...